Systems biology in inflammatory bowel diseases
نویسندگان
چکیده
منابع مشابه
Systems biology in inflammatory bowel diseases: ready for prime time.
PURPOSE OF REVIEW Ulcerative colitis and Crohn's disease are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the United States. IBD results from complex interactions between pathogenic components, including genetic and epigenetic factors, the immune response, and the microbiome, through an unknown sequence of events. The purpose of this r...
متن کاملThe molecular biology of inflammatory bowel diseases.
IBDs (inflammatory bowel diseases) are a group of diseases affecting the gastrointestinal tract. The diseases are multifactorial and cover genetic aspects: susceptibility genes, innate and adaptive responses to inflammation, and structure and efficacy of the mucosal protective barrier. Animal models of IBD have been developed to gain further knowledge of the disease mechanisms. These topics for...
متن کامل[Inflammatory bowel diseases]
OBJECTIVE: To present a review about inflammatory bowel diseases in childhood so that pediatricians become familiar with two diseases (ulcerative colitis and Crohn s disease) that are increasing in incidence. METHODS: Articles of specific gastroenterological journals were analyzed. Information was also obtained from the author s extensive professional experience in the area. RESULTS: The two di...
متن کاملInflammatory bowel diseases.
All rights reserved. Unless special permission in writing is obtained, no part of this publication may be reproduced, stored in a retrieval system, or be transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise. The material contained in this issue was submitted as previously unpublished material, except in the instances in which credit has been given to the so...
متن کاملChemokines in inflammatory bowel diseases.
Uncontrolled activation of mucosal effector cells has been identified as the main pathogenic mechanism involved in the initiation and perpetuation of mucosal inflammation in inflammatory bowel diseases (IBD). The sustained activation of these cells leads to the aberrant production of various pro-inflammatory mediators, which co-ordinated action amplifies the inflammatory process. In this settin...
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ژورنال
عنوان ژورنال: Current Opinion in Gastroenterology
سال: 2014
ISSN: 0267-1379
DOI: 10.1097/mog.0000000000000081